

DAE-Saha Institute of Nuclear Physics
Nuclear Architecture and Mechanics Lab

Unlocking Nuclear Secrets
with Kaushik Sengupta Lab
Join us in unraveling the intricate mechanics of the nucleus and their implications in human disease. Our research focuses on the multifaceted roles of Lamin A in nuclear organization, gene regulation, and cellular biomechanics, with direct relevance to conditions such as dilated cardiomyopathy, muscular dystrophies, and cancer. We employ an interdisciplinary toolkit—ranging from advanced biophysical assays to machine learning—to dissect lamin function and expression, including pioneering studies on lamin dysregulation in ovarian cancer. In our collaborative and intellectually stimulating environment, we believe that curiosity fuels discovery. Your insights and contributions could be the key to advancing our understanding of nuclear architecture and its role in disease. Welcome to a space where science, innovation, and collaboration converge to drive meaningful breakthroughs